Sometimes, as much as I love my family, it’s great to leave the husband and kids at home and get away with just the girls. And what better way to spend quality time with my friends than to spend a vacation together. You don’t need a lot of time. In many cases, a long weekend goes a long way to recharging the batteries.

What makes a destination a perfect girlfriend getaway usually entails a deluxe spa (a definite must!), great restaurants and a relaxing environment, but our two B&B inclusions adequately show that the choice for a relaxing weekend or long weekend excursion does not need to feature a megaresort.

The Water Club—A Signature Hotel by Borgata (www.thewaterclubatborgata.com) is the place to go for spa aficionados, as it boasts one of the most luxurious spas on the East Coast. The weekend I visited, I spent most of my time at the lap pool, ordering spa food service, getting treatments and talking to my girlfriends.

The Immersion Spa, on the 32nd floor, is a 32,000-square-foot sanctuary boasting 16 treatment rooms, floor-to-ceiling windows and amazing views of Atlantic City and the ocean beyond. A 25-yard infinity-edge lap pool, with plush chaises longues, is the centerpiece. Treatments range from massages and facials to cutting-edge water and wrap therapies, and what’s really nice is that they are 30 minutes longer than the standard 50-minute treatments provided at most spas.

When I wasn’t in the spa, my girlfriends and I were enjoying the fabulous restaurants at the resort, especially the Bobby Flay Steakhouse (who says steakhousesare just for men?). The resort attracts top talent from around the world, and we were torn between seeing John Mayer or Chris Rock.

Mohegan Sun (www.mohegansun.com) also boasts a spa that attracts many women. When I visited, the relaxation lounges (separate ones for men and women) were packed with girlfriends. Its 23,000-square-foot Elemis Spa is much quieter, as are its large Jacuzzi, sauna and steam room. The 13 treatment rooms are named for the moons that mark the Mohegan Indian tribe’s seasonal change.

The restaurants at Mohegan Sun offer diverse as well as delicious fare. Jimmy Buffet’s  Margaritaville, the resort’s newest restaurant, is the perfect place for women to catch up over margaritas and cheeseburgersin-paradise. The atmosphere is fun and festive. The two celebrity restaurants—Todd English’s Tuscany and Michael Jordan’s—are great for upscale dinners.

Dancer Farm B&B (www.dancerfarm.com) proves that size is not everything. What better way to celebrate spring’s renewal than with a trip to New Egypt, in Central New Jersey, where the charming Dancer Farm shares 250 rolling acres with a network of horseback and hiking trails, an equestrian center and a winery? Massages can be arranged, and with only 10 guest rooms, peace and quiet is high on the agenda. The state’s famous Jersey Shore is a short drive away.

Want the whole place for you and your friends? Then look no further than The High Pointe Inn (www.thehighpointeinn.com), in West Barnstable on Cape Cod. Four of you can rent out the entire place and enjoy—in the package rate—a pizza party, full breakfast every morning, a three-course dinner at a nearby fine-dining restaurant, evening cocktails, views of the ocean and the dunes of Sandy Neck beach from each room and the freedom to relax in solitude. Its lounge has a healthy selection of DVDs. In the off-season, Cape Cod is a relatively uncrowded jewel, and the B&B is beside one of the most scenic roads in the United States.

Want to escape to foreign climes? The St. Kitts Marriott Resort & The Royal Beach Casino (www.stkittsmarriott.com) offers the largest Vegas-style casino in the Caribbean, eight restaurants, a world-class spa and one of the most beautiful beaches on the island, North Frigate Bay Beach. The sand is golden and soft, and both nonmotorized and motorized water sports are available.

Its Emerald Mist Spa features eight treatment rooms, hot and cold plunge pools, hot tubs, Vichy showers and a Roman bath. For girlfriends traveling together, the salon can host groups of 12 for manicures, pedicures and hair services, and there are plenty of places for the girls to sit around and gab.

Lastly, for women who want a Caribbean island vacation without technically leaving the United States, then Puerto Rico is the place to go. The San Juan Marriott Resort & Stellaris Casino (www.marriott.com) recently underwent a $35 million renovation, and the new look is chic and stylish. The bedrooms now feature 300-thread-count sheets, down comforters, sheeted duvet covers, thick mattresses, plush toppers and superfluffy pillows. All bathrooms have rainforest showerheads and deep tubs, and its interconnecting ground-floor cabana rooms are ideal for groups who want to be close to the pool and resort amenities.